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Current science supports the view that calcium is mainly absorbed in an ionized state in the small intestine through calcium channels in the enterocyte plasma membranes. Vitamin D3 stimulates the induction of calcium-binding proteins, enhancing calcium ion absorption via those channels.
An isotonic calcium preparation does not require lengthy dissolution in the stomach like a tablet, since the calcium and magnesium are largely in an ionized state. An isotonic product is sophisticated in its delivery system as compared to tablets or capsules. Note that the small intestine (and the very first part of the colon) can only absorb about 300-400 mg of calcium at a meal or from supplementation. The remainder is excreted in the feces.
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